Ultrasound-Responsive Calcium Copper Phosphate Nanomaterials Induce Tumor Cell Death via the Synergistic Release of Copper and Calcium
Jieling Qin; Zhenqi Jiang · 2026 · International Journal of Molecular Sciences
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Abstract
Metastatic breast cancer remains a significant therapeutic challenge due to its high invasiveness and resistance to conventional treatments. In this study, an ultrasound-responsive copper-calcium phosphate (Ca19Cu2(PO4)14) nanomaterial is developed for synergistic ion-mediated tumor therapy. The Ca19Cu2(PO4)14 nanomaterials exhibit a uniform morphology and crystalline structure, as well as good colloidal stability. Upon ultrasound irradiation, the release of Cu2+ and Ca2+ is spatiotemporally controlled via mechanical and cavitation effects. In vitro studies using highly metastatic 4T1 cells de
Abstract by Jieling Qin; Zhenqi Jiang, International Journal of Molecular Sciences (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms27042016