DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
Danni A. Gadd; Hannah M. Smith; Donncha Mullin; Ola Chybowska; Robert F. Hillary; Dorien M. Kimenai; Elena Bernabeu; Yipeng Cheng · 2024 · Clinical Epigenetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proBNP may provide new routes for risk stratification. Results In the Generation Scotland cohort (N ≥ 16,963), GDF15 levels were associated with incident dementia, ischaemic stroke and type 2 diabetes, whereas NT-proBNP levels were associated with incident ischaemic heart disease, ischaemic stroke and type 2 diabetes (all PFDR 95%) with levels of GDF15 an
Abstract by Danni A. Gadd; Hannah M. Smith; Donncha Mullin; Ola Chybowska; Robert F. Hillary; Dorien M. Kimenai; Elena Bernabeu; Yipeng Cheng, Clinical Epigenetics (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s13148-024-01734-7