[¹¹C]Methionine PET uptake kinetics in corticotroph pituitary neuroendocrine tumors
Anthime Flaus; Armand Pattée; Guillaume Criton; Nicolas Costes; Elise Levigoureux; Julie Haesebaert; Alexandre Vasiljevic; IMPEC Collaborators · 2026 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract [11C]Methionine ([11C]MET) PET provides high sensitivity to localize corticotroph pituitary neuroendocrine tumors (PitNETs) in de novo Cushing’s disease but remains inconclusive in up to 20% of cases. Current PET protocols rely on late acquisitions (20–40 min post-injection). Since other endocrine tumors present earlier peak tracer uptake, corticotroph PitNETs might also exhibit early differential amino acid uptake, compared to the normal pituitary gland. This exploratory study based on data derived from a previously registered prospective multicenter cohort study (ClinicalTrials.gov
Abstract by Anthime Flaus; Armand Pattée; Guillaume Criton; Nicolas Costes; Elise Levigoureux; Julie Haesebaert; Alexandre Vasiljevic; IMPEC Collaborators, Scientific Reports (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1038/s41598-026-39219-7