Negative / Null Result ReportOpen accessMedicine

Epstein-Barr virus and human papillomavirus infections and genotype distribution in head and neck cancers.

Zeyi Deng; Takayuki Uehara; Hiroyuki Maeda; Masahiro Hasegawa; Sen Matayoshi; Asanori Kiyuna; Shinya Agena; Xiaoli Pan · 2014 · PLoS ONE

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

To investigate the prevalence, genotypes, and prognostic values of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infections in Japanese patients with different types of head and neck cancer (HNC).HPV and EBV DNA, EBV genotypes and LMP-1 variants, and HPV mRNA expression were detected by PCR from fresh-frozen HNC samples. HPV genotypes were determined by direct sequencing, and EBV encoded RNA (EBER) was examined by in situ hybridization.Of the 209 HNC patients, 63 (30.1%) had HPV infection, and HPV-16 was the most common subtype (86.9%). HPV E6/E7 mRNA expression was found in 23 of 60

Abstract by Zeyi Deng; Takayuki Uehara; Hiroyuki Maeda; Masahiro Hasegawa; Sen Matayoshi; Asanori Kiyuna; Shinya Agena; Xiaoli Pan, PLoS ONE (2014) — licensed CC BY 4.0.

Read the full paper (open access)