Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain.
Abida Shaheen; Syed Mahboob Alam; Fahad Azam; Salman Ahmad Saleem; Moosa Khan; Syed Saud Hasan; Afrose Liaquat · 2022 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background and objective Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to investigate the possible influence of the single nucleotide polymorphism (SNP) of OCTN1 on therapeutic efficacy and safety of gabapentinoids in neuropathic pain patients of the Pakistani po
Abstract by Abida Shaheen; Syed Mahboob Alam; Fahad Azam; Salman Ahmad Saleem; Moosa Khan; Syed Saud Hasan; Afrose Liaquat, PLoS ONE (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0266559