The impact of p53 mutation on tumor immune evasion: mechanistic insights and clinical implications
L. Liang; Weidong Wang · 2026 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mutant p53(Mtp53) not only loses its canonical tumor-suppressive functions but also acquires oncogenic gain-of-function properties, positioning it as a central orchestrator in reshaping the tumor immune microenvironment. This review systematically delineates how Mtp53 actively establishes and sustains an immunosuppressive niche through multiple interconnected mechanisms, including chronic inflammation, immune cell dysfunction, reprogramming of cancer-associated fibroblasts, metabolic dysregulation, epigenetic hijacking, and potentially aberrant liquid–liquid phase separation, thereby promoting
Abstract by L. Liang; Weidong Wang, Frontiers in Immunology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2026.1753215