Rapid Accumulation of Virulent Rift Valley Fever Virus in Mice from an Attenuated Virus Carrying a Single Nucleotide Substitution in the M RNA
John C. Morrill; Tetsuro Ikegami; Naoko Yoshikawa-Iwata; Nandadeva Lokugamage; Sungyong Won; Kaori Terasaki; Aya Zamoto‐Niikura; C. J. Peters · 2010 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Rift Valley fever virus (RVFV), a member of the genus Phlebovirus within the family Bunyaviridae, is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, while in livestock it causes fever and high abortion rates. METHODOLOGY/PRINCIPAL FINDINGS: Sequence analysis showed that a wild-type RVFV ZH501 preparation consisted of two major viral subpopulations, with a single nucleotide heterogeneity at nucleotide 847 of M segment (M847); one had a G residue at M847 encoding glycine in a major
Abstract by John C. Morrill; Tetsuro Ikegami; Naoko Yoshikawa-Iwata; Nandadeva Lokugamage; Sungyong Won; Kaori Terasaki; Aya Zamoto‐Niikura; C. J. Peters, PLoS ONE (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0009986