Negative / Null Result ReportOpen accessMedicine· cited by 15

Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study

Adam Stevens; Philip Murray; Jérôme Wojcik; John Raelson; Ekaterina Koledova; Pierre Chatelain; Peter Clayton; _ _ · 2016 · European Journal of Endocrinology

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

OBJECTIVE: Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term follow-up (LTFU) study (Nbib699855). Here, we describe the PREDICT validation (VAL) study (Nbib1419249), which aimed to confirm these genetic associations. DESIGN AND METHODS: Children with GHD (n = 293) or TS (n = 132) were recruited retrospectively from 29 sites in nine countries. All children had completed 1 year of r-hGH therapy. 48 SNPs previou

Abstract by Adam Stevens; Philip Murray; Jérôme Wojcik; John Raelson; Ekaterina Koledova; Pierre Chatelain; Peter Clayton; _ _, European Journal of Endocrinology (2016) — licensed CC BY 4.0.

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