Negative / Null Result ReportOpen accessMedicine· cited by 10

Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats

Pinar Sargin; Mark F. Roethle; Shuang Jia; Tarun Pant; Ashley E. Ciecko; Samantha N. Atkinson; Nita H. Salzman; Ru‐Jeng Teng · 2022 · Gut Microbes

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

The finding, in one line

“ND with Lp299v did not improve survival.”

Abstract

The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves gut barrier function and reduces systemic inflammation, we studied its effects in spontaneously diabetic DRlyp/lyp rats provided a normal cereal diet (ND) or a gluten-free hydrolyzed casein diet (HCD). All rats provided ND developed diabetes (62.5±7.7 days); combining ND with Lp299v did not improve survival. Diabetes was delayed by HCD (72.2±9.4 day

Abstract by Pinar Sargin; Mark F. Roethle; Shuang Jia; Tarun Pant; Ashley E. Ciecko; Samantha N. Atkinson; Nita H. Salzman; Ru‐Jeng Teng, Gut Microbes (2022) — licensed CC BY 4.0.

Read the full paper (open access)