Phosphodiesterase 4 (PDE 4) Inhibition Reduces Ischemia-Reperfusion-Induced Leucocyte Infiltration, Apoptosis and Mitochondrial Fission Markers in Mice Skeletal Muscles Four Hours After Ischemia Onset.
Charles AL; Tetsi L; Quiring G; Barnig C; Giannini M; Meyer A; Lejay A; Lugnier C · 2026 · Muscles (Basel, Switzerland)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Peripheral arterial disease is a leading cause of amputation and/or death worldwide. Phosphodiesterase 4 (PDE 4) inhibitors demonstrated beneficial effects in ischemia-reperfusion (IR) settings, but whether PDE 4 inhibition protects…
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Metadata source: Europe PMC · DOI 10.3390/muscles5010019