Comparison of pathogenicity of subtype H9 avian influenza wild-type viruses from a wide geographic origin expressing mono-, di-, or tri-basic hemagglutinin cleavage sites
Rokshana Parvin; Jan Schinkoethe; Christian Grund; Reiner Ulrich; Franziska Bönte; Klaus P. Behr; Matthias Voß; Mohammed A. Samad · 2020 · Veterinary Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
An intravenous pathogenicity index (IVPI) of > 1.2 in chickens or, in case of subtypes H5 and H7, expression of a polybasic hemagglutinin cleavage site (HACS), signals high pathogenicity (HP). Viruses of the H9N2-G1 lineage, which spread across Asia and Africa, are classified to be of low pathogenicity although, in the field, they became associated with severe clinical signs and epizootics in chickens. Here we report on a pre-eminent trait of recent H9N2-G1 isolates from Bangladesh and India, which express a tribasic HACS (motif PAKSKR-GLF; reminiscent of an HPAIV-like polybasic HACS) and comp
Abstract by Rokshana Parvin; Jan Schinkoethe; Christian Grund; Reiner Ulrich; Franziska Bönte; Klaus P. Behr; Matthias Voß; Mohammed A. Samad, Veterinary Research (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13567-020-00771-3