Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice
Kayla M. Quinnies; Paul J. Bonthuis; Erin P. Harris; Savera R. J. Shetty; Emilie F. Rissman · 2015 · Biology of Sex Differences
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as
Abstract by Kayla M. Quinnies; Paul J. Bonthuis; Erin P. Harris; Savera R. J. Shetty; Emilie F. Rissman, Biology of Sex Differences (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13293-015-0026-x