The effect of Cornus mas L. fruit extract supplementation on glycemic control, insulin resistance, and adiponectin levels in patients with metabolic dysfunction-associated steatotic liver disease: a double-blind randomized controlled clinical trial
Zohreh Sadat Sangsefidi; Abbas Ali Sangouni; Faezeh Yarhosseini; Mahdieh Hosseinzadeh; Mohsen Akhondi-Meybodi; Alimohammad Ranjbar; Farzan Madadizadeh; Hassan Mozaffari-Khosravi · 2026 · Journal of Health, Population and Nutrition
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Available evidence regarding effect of Cornus mas L. fruit extract (CMFE) as an anthocyanins source on glycemic control, insulin resistance, and adiponectin levels among metabolic dysfunction-associated steatotic liver disease (MASLD) patients is limited and controversial. Thus, this study aimed to assess effect of CMFE on glycemic control, insulin resistance, and adiponectin levels in MASLD patients. Methods This double-blind, randomized controlled clinical trial was carried out among 50 MASLD patients for 12 weeks. The participants were randomly categorized into the CMFE
Abstract by Zohreh Sadat Sangsefidi; Abbas Ali Sangouni; Faezeh Yarhosseini; Mahdieh Hosseinzadeh; Mohsen Akhondi-Meybodi; Alimohammad Ranjbar; Farzan Madadizadeh; Hassan Mozaffari-Khosravi, Journal of Health, Population and Nutrition (2026) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
The Effect of Postpartum Vitamin A and Beef Liver supplementation on Infant Acute Respiratory Infection and Diarrhea
Negative / Null Result ReportCadmium and selenium blood levels in association with congestive heart failure in diabetic and prediabetic patients: a cross-sectional study from the national health and nutrition examination survey
Negative / Null Result ReportCurcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial
Replication FailureSex-specific associations between type 2 diabetes and muscle health in middle-aged adults
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1186/s41043-025-01186-6