Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters
Darryl Falzarano; David Safronetz; Joseph Prescott; Andrea Marzi; Friederike Feldmann; Heinz Feldmann · 2015 · Emerging infectious diseases
WASTE classifies this as Failed Experiment Report · AI classification, approximate
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The finding, in one line
“In mouse and hamster models, treatment did not improve survival.”
Abstract
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
Abstract by Darryl Falzarano; David Safronetz; Joseph Prescott; Andrea Marzi; Friederike Feldmann; Heinz Feldmann, Emerging infectious diseases (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3201/eid2106.150176