Impairment of retrograde neuronal transport in oxaliplatin-induced neuropathy demonstrated by molecular imaging.
Dawid Schellingerhout; Lucia G LeRoux; Brian P Hobbs; Sebastian Bredow · 2012 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background and purpose The purpose of our study was to utilize a molecular imaging technology based on the retrograde axonal transport mechanism (neurography), to determine if oxaliplatin-induced neurotoxicity affects retrograde axonal transport in an animal model. Materials and methods Mice (n = 8/group) were injected with a cumulative dose of 30 mg/kg oxaliplatin (sufficient to induce neurotoxicity) or dextrose control injections. Intramuscular injections of Tetanus Toxin C-fragment (TTc) labeled with Alexa 790 fluorescent dye were done (15 ug/20 uL) in the left calf muscles, and in vivo flu
Abstract by Dawid Schellingerhout; Lucia G LeRoux; Brian P Hobbs; Sebastian Bredow, PLoS ONE (2012) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0045776