Correlation of Moxifloxacin Concentration, C-Reactive Protein, and Inflammatory Cytokines on QTc Interval in Rifampicin-Resistant Tuberculosis Patients Treated with Shorter Regimens
Tutik Kusmiati; Ni Made Mertaniasih; Johanes Nugroho Eko Putranto; Budi Suprapti; Nadya Luthfah; Soedarsono Soedarsono; Winariani Koesoemoprodjo; Aryani Prawita Sari · 2022 · Acta Medica Indonesiana
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Drug-resistant tuberculosis (DR-TB) is a global health concern. QTc prolongation is a serious adverse effect in DR-TB patients receiving a shorter regimen. This study aimed to evaluate the correlation of moxifloxacin concentration, CRP, and inflammatory cytokines with QTc interval in DR-TB patients treated with a shorter regimen. Methods: This study was performed in 2 groups of rifampicin-resistant (RR-TB) patients receiving shorter regimens. Correlation for all variables was analyzed. Results: CRP, IL-1β, and QTc baseline showed significant differences between 45 RR-TB patients on
Abstract by Tutik Kusmiati; Ni Made Mertaniasih; Johanes Nugroho Eko Putranto; Budi Suprapti; Nadya Luthfah; Soedarsono Soedarsono; Winariani Koesoemoprodjo; Aryani Prawita Sari, Acta Medica Indonesiana (2022) — licensed CC BY 4.0.
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