Increased or decreased numbers of CpG dinucleotide motifs in the genome of influenza A virus do not affect in vitro virus phenotype.
Susma; Spronken; van Nieuwkoop; Kalverda; Gultyaev; Fouchier; van den Hoogen · 2026 · Journal of virology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Cytosine-phosphate-guanine (CpG) dinucleotide motifs are the most underrepresented motifs in RNA virus genomes, including those of the influenza A viruses (IAV). Previous studies have indicated that increasing the number of CpG motifs in…
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Metadata source: PubMed · DOI 10.1128/jvi.00047-26