Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease
John P Grogan; Demitra Tsivos; Laura Smith; Brogan E Knight; Rafal Bogacz; Alan Whone; Elizabeth J Coulthard · 2017 · eLife
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Emerging evidence suggests that dopamine may modulate learning and memory with important implications for understanding the neurobiology of memory and future therapeutic targeting. An influential hypothesis posits that dopamine biases reinforcement learning. More recent data also suggest an influence during both consolidation and retrieval. Eighteen Parkinson's disease patients learned through feedback ON or OFF medication, with memory tested 24 hr later ON or OFF medication (4 conditions, within-subjects design with matched healthy control group). Patients OFF medication during learning decre
Abstract by John P Grogan; Demitra Tsivos; Laura Smith; Brogan E Knight; Rafal Bogacz; Alan Whone; Elizabeth J Coulthard, eLife (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.7554/elife.26801