Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial
Stefan Hagel; Friedhelm Bach; Thorsten Brenner; Hendrik Bracht; Alexander Brinkmann; Thorsten Annecke; Andreas Höhn; Markus A. Weigand · 2022 · Intensive Care Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
PURPOSE: Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. METHODS: Randomized, multicenter, controlled…
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Metadata source: OpenAlex · DOI 10.1007/s00134-021-06609-6