Update on the Symptomatic Treatment of Huntington’s Disease: From Pathophysiology to Clinical Practice
Gonzalo Olmedo‐Saura; E Bernardi; Lidia Bojtos; Saül Martínez‐Horta; Javier Pagonabarraga; Jaime Kulisevsky; Jesús Pérez‐Pérez · 2025 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Huntington's disease (HD) is the most common autosomal dominant neurodegenerative disorder, characterized by a triad of motor dysfunction, cognitive decline, and psychiatric disturbances. While recent efforts have focused on developing disease-modifying therapies, no treatment has yet demonstrated clinical efficacy. As a result, symptomatic treatment remains the cornerstone of care. However, high-quality evidence from large randomized trials is limited, and therapeutic decisions must rely on clinical expertise and extrapolation from other neurological or psychiatric conditions. This narrative
Abstract by Gonzalo Olmedo‐Saura; E Bernardi; Lidia Bojtos; Saül Martínez‐Horta; Javier Pagonabarraga; Jaime Kulisevsky; Jesús Pérez‐Pérez, International Journal of Molecular Sciences (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms26136220