Adding free leucine to a balanced essential amino acid mixture suppresses intracellular transamination of isoleucine and valine in healthy older adults.
Knezek SB; Engelen MPKJ; Coyle KS; Perez CN; Deutz NEP · 2026 · Clinical nutrition (Edinburgh, Scotland)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Adding leucine (LEU) to protein meals enhances protein anabolism, but excess LEU reduces valine (VAL) and isoleucine (ILE) plasma concentrations. We examined in older adults whether additional LEU added to an essential amino…
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Metadata source: Europe PMC · DOI 10.1016/j.clnu.2026.106659