Discovery of IS1515 transposition into the Spn9802 fragment of Streptococcus pneumoniae and its implications for PCR-based diagnostic assays.
Toorop MMA; Kraakman MEM; Claas ECJ; Wessels E; Boers SA · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
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Abstract (excerpt)
This study investigates a diagnostic challenge in detecting Streptococcus pneumoniae using a Spn9802-targeted PCR assay. Four S. pneumoniae isolates tested lytA-positive but Spn9802-negative due to an insertion sequence (IS1515) within…
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Metadata source: Europe PMC · DOI 10.1007/s10096-025-05328-w