Negative / Null Result ReportOpen accessMedicine· cited by 28

Impact of baseline and nadir neutrophil index in non-small cell lung cancer and ovarian cancer patients: Assessment of chemotherapy for resolution of unfavourable neutrophilia

Andreas Carus; Howard Gurney; Val Gebski; Paul R. Harnett; Rina Hui; Richard Kefford; Nicholas Wilcken; Morten Ladekarl · 2013 · Journal of Translational Medicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Chronic inflammation has been recognized to foster tumour development. Whether chemotherapy can be used to neutralize chronic inflammation is unclear. We evaluated baseline and nadir neutrophils in 111 patients (pts.) with non-small cell lung cancer (NSCLC) and 118 pts. with ovarian cancer (OC) treated with chemotherapy administered with dose-individualization to achieve nadir neutropenia of 1.5. We used predefined baseline neutrophil cut-offs 4.5 × 109/L (NSCLC) and 3.9 × 109/L (OC). Absence of chemotherapy-induced nadir neutropenia (CTCAE grade 0, neutrophils ≥ LLN) was seen in 23% of OC and

Abstract by Andreas Carus; Howard Gurney; Val Gebski; Paul R. Harnett; Rina Hui; Richard Kefford; Nicholas Wilcken; Morten Ladekarl, Journal of Translational Medicine (2013) — licensed CC BY 4.0.

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