Evaluation of early left-sided cardiac reverse remodeling under combined therapy of sacubitril-valsartan and spironolactone compared with angiotensin-converting enzyme inhibitors and spironolactone
Wioletta Sacharczuk; Rafał Dankowski; Stefan Ożegowski; Maciej Rojna; Andrzej Szyszka · 2023 · Frontiers in Cardiovascular Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
We aimed to compare therapies of sacubitril/valsartan + spironolactone (S/V + S) with angiotensin-converting enzyme inhibitors + spironolactone (ACEI + S) on the left-sided cardiac reverse remodeling (L-CRR). The second objective was to analyze the usefulness of GLS and LVEF in response to therapy.Methods78 patients (mean age 63.4 years, 20 females) with symptomatic heart failure with reduced ejection fraction were randomized to groups of equal numbers, i.e., 39 patients, and started on therapy of S/V + S or ACEI + S. Second evaluations were made after 6–8 weeks of therapy.ResultsGLS changed f
Abstract by Wioletta Sacharczuk; Rafał Dankowski; Stefan Ożegowski; Maciej Rojna; Andrzej Szyszka, Frontiers in Cardiovascular Medicine (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3389/fcvm.2023.1103688