The multiple mechanisms and modes of cell death after acetaminophen overdose
Hartmut Jaeschke; Anup Ramachandran · 2025 · Exploration of Digestive Diseases
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Acetaminophen (APAP)-induced liver injury and acute liver failure is a significant clinical problem worldwide; in addition, APAP overdoses in animals or in cell culture are used as popular models to study drug-induced liver injury mechanisms and test therapeutic interventions. Early assumptions that APAP toxicity is caused by a single mechanism resulting in a defined mode of cell death in hepatocytes had to be questioned when over the years many different mechanisms and modes of cell death were reported. Although many of the contradictory results and conclusions reported over the years can be
Abstract by Hartmut Jaeschke; Anup Ramachandran, Exploration of Digestive Diseases (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.37349/edd.2025.100569