Adipocyte-specific modulation of 11β-HSD enzymes for the treatment of obesity in male mice.
Matienzo ME; Lee J; Lim S; Evallo E; Lee CM; Kim K; Park MJ; Kim DI · 2025 · American journal of physiology. Cell physiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Glucocorticoids (GCs) are potent regulators of energy balance and adipose tissue function, making them attractive targets for obesity treatments. The local activation and inactivation of GCs are mediated by two key enzymes:…
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Metadata source: Europe PMC · DOI 10.1152/ajpcell.00978.2024