The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats
Anoek L. I. van Leeuwen; Nicole A. M. Dekker; Paul Van Slyke; Esther de Groot; Marc G. Vervloet; Joris J. T. H. Roelofs; Matijs van Meurs; Charissa E. van den Brom · 2021 · Intensive Care Medicine Experimental
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic shock-induced vascular leakage. We hypothesized that as a consequence of vascular leakage, renal perfusion and function is impaired and that activating Tie2 restores renal perfusion and function. Methods Rats underwent 1 h of hemorrhagic shock and were treated with either vasculotide or PBS as control, followed by fluid resuscitation for 4 h. Microcirculatory perfusion w
Abstract by Anoek L. I. van Leeuwen; Nicole A. M. Dekker; Paul Van Slyke; Esther de Groot; Marc G. Vervloet; Joris J. T. H. Roelofs; Matijs van Meurs; Charissa E. van den Brom, Intensive Care Medicine Experimental (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s40635-021-00389-5