Lumateperone monotherapy for major depressive episodes associated with bipolar disorder: efficacy and safety in a randomized placebo-controlled trial.
Correll CU; Durgam S; Kozauer SG; Lakkis HD; Chen C; Vanover KE; Mates S; Davis RE · 2026 · International clinical psychopharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
This Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of lumateperone to treat bipolar depression. Patients (18-75 years) with bipolar I or bipolar II disorder experiencing a major depressive…
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Metadata source: Europe PMC · DOI 10.1097/yic.0000000000000597