Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human
Y Yamamura; Chisa Nakashima; Atsushi Otsuka · 2024 · Frontiers in Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three main factors: dysregulation of the immune response, barrier dysfunction, and pruritus. In the lesional skin of AD, various innate immune cells, including Th2 cells, type 2 innate lymphoid cells (ILC2s), and basophils, produce Th2 cytokines [interleukin (IL)-4, IL-5, IL-13, IL-31]. Alarmins such as TSLP, IL-25, and IL-33 are also produced by epidermal keratinocytes, amplifying type 2 inflammation. In the chronic phase, not only Th2 cells but also Th22 and Th17 cells increase in number, leading to suppre
Abstract by Y Yamamura; Chisa Nakashima; Atsushi Otsuka, Frontiers in Medicine (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fmed.2024.1342176