Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death
Zhonglei He; Kangze Liu; Eline Manaloto; Alan Casey; George P. Cribaro; Hugh J. Byrne; Furong Tian; Carlos Barcia · 2018 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined with AuNP to achieve synergistic anti-cancer cytotoxicity. To explore synergistic mechanisms, we demonstrate both rate of AuNP uptake and total amount accumulated in U373MG Glioblastoma multiforme (GBM) cells are significantly increased when exposed to 75 kV CAP generated by dielectric barrier discharge. No significant changes in the physical parameters of AuNP were caused by CAP but acti
Abstract by Zhonglei He; Kangze Liu; Eline Manaloto; Alan Casey; George P. Cribaro; Hugh J. Byrne; Furong Tian; Carlos Barcia, Scientific Reports (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-018-23262-0