GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory
Shangkai Gao; Léa Décarie-Spain; Cindy Gu; Giulia Mazzini; Scott E. Kanoski; Tito Borner · 2026 · Comprehensive physiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Glucagon-like peptide-1 (GLP-1) is a nutrient-responsive hormone classically associated with glucose homeostasis and food intake control, yet its receptor is broadly expressed throughout the central nervous system (CNS) in circuits governing complex cognitive processes. Here, we synthesize emerging evidence from preclinical models and human studies demonstrating that GLP-1 receptor (GLP-1R) signaling modulates multiple cognitive domains, including reward and motivational processes relevant to obesity and substance use disorder, affective-related behaviors, and learning and memory. We propose a
Abstract by Shangkai Gao; Léa Décarie-Spain; Cindy Gu; Giulia Mazzini; Scott E. Kanoski; Tito Borner, Comprehensive physiology (2026) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
Negative / Null Result ReportDuodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Negative / Null Result ReportStenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis
Negative / Null Result ReportEffects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
Replication FailureA Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Negative / Null Result ReportSpironolactone for Heart Failure with Preserved Ejection Fraction
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1002/cph4.70129