Negative / Null Result ReportOpen accessMedicine· cited by 30

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

Ngan T.K. Tran; Stella Aslibekyan; Hemant K. Tiwari; Degui Zhi; Yun Ju Sung; Steven C. Hunt; DC Rao; Ulrich Broeckel · 2015 · Frontiers in Genetics

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Proprotein convertase subtilisin/kexin type 9 (encoded by PCSK9) plays a well-known role in the regulation of low-density lipoprotein (LDL) receptors, and an inhibitor of this enzyme is a promising new therapeutic for hyperlipidemia. Recently, animal and human studies also implicate PCSK9 genetic variation in the regulation of blood pressure. The goal of this study was to examine if common and rare polymorphisms in PCSK9 are associated with blood pressure in an African-American population at high risk for cardiovascular disease. Using genomic data assayed on the Affymetrix 6.0 array (n = 1199)

Abstract by Ngan T.K. Tran; Stella Aslibekyan; Hemant K. Tiwari; Degui Zhi; Yun Ju Sung; Steven C. Hunt; DC Rao; Ulrich Broeckel, Frontiers in Genetics (2015) — licensed CC BY 4.0.

Read the full paper (open access)