Proteins Do Not Replicate, They Precipitate: Phase Transition and Loss of Function Toxicity in Amyloid Pathologies
Kariem Ezzat; Andrea Sturchio; Alberto J. Espay · 2022 · Biology
WASTE classifies this as Abandoned Hypothesis · AI classification, approximate
A hypothesis was tested and not supported — a dead end worth knowing about before you pursue it.
Abstract (excerpt)
Protein aggregation into amyloid fibrils affects many proteins in a variety of diseases, including neurodegenerative disorders, diabetes, and cancer. Physicochemically, amyloid formation is a phase transition process, where soluble…
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Metadata source: Crossref · DOI 10.3390/biology11040535