A Single Dose of Baicalin Has No Clinically Significant Effect on the Pharmacokinetics of Cyclosporine A in Healthy Chinese Volunteers
Ruijuan Liu; Xia Li; Jingyao Wei; Shuaibing Liu; Yuanyuan Chang; Jiali Zhang; Ji Zhang; Xiaojian Zhang · 2019 · Frontiers in Pharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Despite its narrow therapeutic window and large inter-individual variability, cyclosporine A (CsA) is the first-line therapy following organ transplantation. Metabolized mainly by CYP3A and being a substrate of P-glycoprotein (P-gp), CsA is susceptible to drug-drug interactions. Baicalin (BG) is a drug used for adjuvant therapy of hepatitis in traditional Chinese medicine. Since its aglycone Baicalein (B) inhibits CYP3A and P-gP, co-administration might affect CsA pharmacokinetics. This study investigated the effect of BG on CsA pharmacokinetics. In a two-period study, 16 healthy volunteers re
Abstract by Ruijuan Liu; Xia Li; Jingyao Wei; Shuaibing Liu; Yuanyuan Chang; Jiali Zhang; Ji Zhang; Xiaojian Zhang, Frontiers in Pharmacology (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fphar.2019.00518