Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration*
Nuala J. Meyer; John P. Reilly; Brian J. Anderson; Jessica A. Palakshappa; Tiffanie K. Jones; Thomas Dunn; M.G.S. Shashaty; Rui Feng · 2017 · Critical Care Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“OBJECTIVE: Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in randomized trials.”
Abstract (excerpt)
OBJECTIVE: Plasma interleukin-1 beta may influence sepsis mortality, yet recombinant human interleukin-1 receptor antagonist did not reduce mortality in randomized trials. We tested for heterogeneity in the treatment effect of recombinant…
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Metadata source: OpenAlex · DOI 10.1097/ccm.0000000000002749