A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder
Anne Krogh Nøhr; Morten Lindow; Annika Forsingdal; Samuel Demharter; Troels T. Nielsen; R. Buller; Ida Moltke; Morana Vitezic · 2021 · Neuropsychopharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed. We perform gene expression analyses and explore sources of variability in peripheral blood related to antidepressant treatment and treatment response in patients suffering from recurrent MDD at baseline and after 8 weeks of treatment. The study includes 281 patients, which were randomized to 8 weeks of treatment with vortioxetine (N = 184) or placebo (N = 97). To our knowledge, this is the largest dataset including both gene expression in blood and pl
Abstract by Anne Krogh Nøhr; Morten Lindow; Annika Forsingdal; Samuel Demharter; Troels T. Nielsen; R. Buller; Ida Moltke; Morana Vitezic, Neuropsychopharmacology (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41386-021-01002-9