Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial
Eleni Karakike; Brendon P. Scicluna; Maria Roumpoutsou; Ioannis Mitrou; Niki Karampela; Athanasios Karageorgos; Konstantinos Psaroulis; Eleni Massa · 2022 · Critical Care
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome. METHODS: We conducted a multicenter, randomized, clinical trial in patients with sepsis. Participants with ratio of partial oxygen pressure to fraction of inspired oxygen less than 200 and more than 3 SOFA points from systems other than the respiratory function were enrolled betw
Abstract by Eleni Karakike; Brendon P. Scicluna; Maria Roumpoutsou; Ioannis Mitrou; Niki Karampela; Athanasios Karageorgos; Konstantinos Psaroulis; Eleni Massa, Critical Care (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s13054-022-04055-4