Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications
Lara Mariah Lange; Zih‐Hua Fang; Mary B. Makarious; Nicole Kuznetsov; Kajsa Atterling Brolin; Shannon Ballard; Soraya Bardien; Maria Leila M. Doquenia · 2026 · The Lancet Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The genetic architecture of Parkinson's disease varies considerably across ancestries, yet most previous genetic studies have focused on individuals of European ancestry. We aimed to characterise the distribution of established Parkinson's disease causal variants, as well as risk-associated variants with clinical implications (ie, variants in genes involved in pathways targeted by ongoing clinical trials), across ancestrally diverse populations. METHODS: We conducted a multi-ancestry, observational, cross-sectional genetic study using retrospective data from the Global Parkinson's
Abstract by Lara Mariah Lange; Zih‐Hua Fang; Mary B. Makarious; Nicole Kuznetsov; Kajsa Atterling Brolin; Shannon Ballard; Soraya Bardien; Maria Leila M. Doquenia, The Lancet Neurology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/s1474-4422(26)00198-5