Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study
Siaw Cheok Liew; Esha Dasgupta; Shew Fung Wong; Nagarajah Lee; Najeeb Safdar; Adawiyah Jamil · 2012 · Nutrition Journal
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels. METHODS: This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fa
Abstract by Siaw Cheok Liew; Esha Dasgupta; Shew Fung Wong; Nagarajah Lee; Najeeb Safdar; Adawiyah Jamil, Nutrition Journal (2012) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/1475-2891-11-1