A pilot, randomized, placebo-controlled trial of rimegepant on visceral sensation and symptoms in nonconstipation IBS pain.
Halawi H; Matar A; Wang I; Jencks KJ; Busciglio I; Eckert D; Harmsen WS; Camilleri M · 2026 · American journal of physiology. Gastrointestinal and liver physiology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…
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Metadata source: Europe PMC · DOI 10.1152/ajpgi.00394.2025