Harnessing Novel Tetra-Synergistic Bilosomes for Effective Otomycosis Management: Integrated In-Vitro, Microbiological and In-vivo Studies
Abdurrahman M. Fahmy; Osama Saher; Heba Attia; Michael M. Farag; Sadek Ahmed · 2026 · AAPS PharmSciTech
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract This study introduces and statistically optimizes novel Tetra-Synergistic Bilosomes (TSB), an advanced nano-platform for topical delivery of voriconazole (VOR) in otomycosis therapy. The term “Tetra-Synergistic” reflects the incorporation of four complementary components: Cremophor® EL, sodium deoxycholate, Brij® 58, and Brij® S2, working in synergy to enhance therapeutic efficacy. TSB was fabricated using the thin-film hydration method and optimized through a 2 3 D-optimal design. Three formulation factors were investigated: Cremophor® EL: VOR ratio, sodium deoxycholate: cholesterol
Abstract by Abdurrahman M. Fahmy; Osama Saher; Heba Attia; Michael M. Farag; Sadek Ahmed, AAPS PharmSciTech (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1208/s12249-026-03342-5