4-Aminobutyrate Aminotransferase (ABAT): Genetic and Pharmacological Evidence for an Involvement in Gastro Esophageal Reflux Disease
Johan Jirholt; Bengt Åsling; Paul Hammond; Geoffrey P. Davidson; Mikael Knutsson; Anna Walentinsson; Jörgen Jensen; Anders Lehmann · 2011 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Gastro-esophageal reflux disease (GERD) is partly caused by genetic factors. The underlying susceptibility genes are currently unknown, with the exception of COL3A1. We used three independent GERD patient cohorts to identify GERD susceptibility genes. Thirty-six families, demonstrating dominant transmission of GERD were subjected to whole genome microsatellite genotyping and linkage analysis. Five linked regions were identified. Two families shared a linked region (LOD 3.9 and 2.0) on chromosome 16. We used two additional independent GERD patient cohorts, one consisting of 219 trios (affected
Abstract by Johan Jirholt; Bengt Åsling; Paul Hammond; Geoffrey P. Davidson; Mikael Knutsson; Anna Walentinsson; Jörgen Jensen; Anders Lehmann, PLoS ONE (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0019095