Insights into Photo Degradation and Stabilization Strategies of Antibody–Drug Conjugates with Camptothecin Payloads
Shukun Luo; Joshua Bulos; Ricky Uroza; Yimeng Zhao; Xiao Pan; Yue Su; Haibo Qiu; Babatunde O. Olagunju · 2025 · Pharmaceutics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Photostability assessment is a critical component in the development of drug products, particularly for antibody–drug conjugates (ADCs) containing light-sensitive small molecules such as camptothecin (CPT) and its derivatives. ADCs conjugated with CPT derivative payloads often require extensive formulation and drug product development to ensure product stability due to their unique light-induced degradation pathways. In this study, we assessed the photostability of two ADC molecules with a CPT derivative payload (deruxtecan, DXd). Methods: Following light exposure, the stability of
Abstract by Shukun Luo; Joshua Bulos; Ricky Uroza; Yimeng Zhao; Xiao Pan; Yue Su; Haibo Qiu; Babatunde O. Olagunju, Pharmaceutics (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/pharmaceutics17111397