Parkinson's disease: pathogenesis and therapeutic strategies
Shanshan Zhang; Tingyu Wang; Ye Peng; Qianchen Wang; Zhao Zhang; Shifeng CHU; Hefei Huang; Naihong Chen · 2026 · Molecular Biomedicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairments such as bradykinesia, tremor, and rigidity. Its neuropathological hallmarks include the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and the aggregation of α-synuclein (α-syn) into Lewy bodies (LBs), which gradually spread to other central nervous system regions and peripheral tissues. The etiology of PD is multifactorial, involving a complex interplay of genetic predisposition, aging, environmental exposures, and lifestyle factors. Disease pathogenesis
Abstract by Shanshan Zhang; Tingyu Wang; Ye Peng; Qianchen Wang; Zhao Zhang; Shifeng CHU; Hefei Huang; Naihong Chen, Molecular Biomedicine (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s43556-026-00445-0