Replication FailureOpen accessMedicine· cited by 40

Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus

Lena Hafrén; Elísabet Einarsdóttir; Erna Kentala; Sari Hammarén‐Malmi; Mahmood F. Bhutta; Carol J. MacArthur; Beth Wilmot; Margaretha L. Casselbrant · 2015 · PLoS ONE

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

The finding, in one line

“Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts.”

Abstract

BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We investigated 53 gene polymorphisms in a Finnish cohort of 624 cases and 778 controls. A positive association signal was followed up in a tagging approach and tested in an independent Finnish cohort of 205 cases, in a British cohort of 1269 trios, as well as in two cohorts from the United States (US); on

Abstract by Lena Hafrén; Elísabet Einarsdóttir; Erna Kentala; Sari Hammarén‐Malmi; Mahmood F. Bhutta; Carol J. MacArthur; Beth Wilmot; Margaretha L. Casselbrant, PLoS ONE (2015) — licensed CC BY 4.0.

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