Association between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response after neoadjuvant chemoradiotherapy and resection
Fang He; Huai‐Qiang Ju; Yi Ding; Zhiqiang Jiang; Zhenhui Li; Bo Huang; Xiuhong Wang; Yuanyuan Zhao · 2020 · British Journal of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: For patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT). METHODS: The pCR individuals who received different ACT cycles were paired by propensity score matching. Overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were calculated by Kaplan-Meier and log-rank test. RESULTS: In total, 1041 pCR individuals were identified from 5567 LARC cases.
Abstract by Fang He; Huai‐Qiang Ju; Yi Ding; Zhiqiang Jiang; Zhenhui Li; Bo Huang; Xiuhong Wang; Yuanyuan Zhao, British Journal of Cancer (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41416-020-0989-1