Targeting the sirtuin 6–NF-κB p65 axis by 6-hydroxyhyoscyamine hydrobromide: a deacetylation-driven new therapy for diabetic wounds
Junren Chen; Siqi Qin; Ziwei Xing; Feng Wan; Jie Yin; Cheng Peng; Dan Li · 2026 · Cellular & Molecular Biology Letters
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
BACKGROUND: Diabetic wounds are a debilitating complication of diabetes mellitus with a high rate of amputation and mortality. 6-Hydroxyhyoscyamine hydrobromide (6-HH) is a belladonna alkaloid with smooth-muscle-relaxing and…
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Metadata source: OpenAlex · DOI 10.1186/s11658-025-00856-x