CAR T-Cell Targeting of Macrophage Colony-Stimulating Factor Receptor
Daniela Achkova; Richard Beatson; John Maher · 2022 · Cells
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Macrophage colony-stimulating factor receptor (M-CSFR) is found in cells of the mononuclear phagocyte lineage and is aberrantly expressed in a range of tumours, in addition to tumour-associated macrophages. Consequently, a variety of cancer therapies directed against M-CSFR are under development. We set out to engineer chimeric antigen receptors (CARs) that employ the natural ligands of this receptor, namely M-CSF or interleukin (IL)-34, to achieve specificity for M-CSFR-expressing target cells. Both M-CSF and IL-34 bind to overlapping regions of M-CSFR, although affinity of IL-34 is significa
Abstract by Daniela Achkova; Richard Beatson; John Maher, Cells (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/cells11142190