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Abandoned HypothesisMedicine

Formaldehyde metabolism in the biocatalytic upgrading of lignin.

Lalande AT; Eltis LD · 2026 · Current opinion in biotechnology

WASTE classifies this as Abandoned Hypothesis · AI classification, approximate

A hypothesis was tested and not supported — a dead end worth knowing about before you pursue it.

Abstract (excerpt)

Formaldehyde is a toxic metabolite generated in the bacterial catabolism of lignin-derived aromatic compounds (LDACs) through the oxidative O-demethylation of methoxylated aromatics. Microbial cell factories designed to convert LDACs to…

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Metadata source: Europe PMC · DOI 10.1016/j.copbio.2026.103526