Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology
Arthur Wickenhagen; Meaghan Flagg; Julia R. Port; Claude Kwe Yinda; Kerry Goldin; Shane Gallogly; Jonathan E. Schulz; Tessa Lutterman · 2025 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The emergence of the Omicron lineage represented a major genetic drift in SARS-CoV-2 evolution. This was associated with phenotypic changes including evasion of pre-existing immunity and decreased disease severity. Continuous evolution within the Omicron lineage raised concerns of potential increased transmissibility and/or disease severity. To address this, we evaluate the fitness and pathogenesis of contemporary Omicron variants XBB.1.5, XBB.1.16, EG.5.1, and JN.1 in the upper (URT) and lower respiratory tract (LRT). We compare in vivo infection in Syrian hamsters with infection in primary h
Abstract by Arthur Wickenhagen; Meaghan Flagg; Julia R. Port; Claude Kwe Yinda; Kerry Goldin; Shane Gallogly; Jonathan E. Schulz; Tessa Lutterman, Nature Communications (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-55938-3